Evolution of Disease Burden Over Five Years in a Multicenter Inception Systemic Lupus Erythematosus Cohort
Identifieur interne : 000621 ( Canada/Analysis ); précédent : 000620; suivant : 000622Evolution of Disease Burden Over Five Years in a Multicenter Inception Systemic Lupus Erythematosus Cohort
Auteurs : M. B. Urowitz [Canada] ; D. D. Gladman [Canada] ; D. Ibanez [Canada] ; P. R. Fortin [Canada] ; S. C. Bae [Corée du Sud] ; C. Gordon [Royaume-Uni] ; A. Clarke [Canada] ; S. Bernatsky [Canada] ; J. G. Hanly [Canada] ; D. Isenberg [Royaume-Uni] ; A. Rahman [Mexique] ; J. Sanchez-Guerrero [Mexique] ; D. J. Wallace [États-Unis] ; E. Ginzler [États-Unis] ; G. S. Alarcon [Royaume-Uni] ; J. T. Merrill [États-Unis] ; I. N. Bruce [Royaume-Uni] ; G. Sturfelt [Suède] ; O. Nived [Suède] ; K. Steinsson [Islande] ; M. Khamashta [Royaume-Uni] ; M. Petri [États-Unis] ; S. Manzi [États-Unis] ; R. Ramsey-Goldman [États-Unis] ; M. A. Dooley [États-Unis] ; R. F. Van Vollenhoven [Suède] ; M. Ramos [Espagne] ; T. Stoll [Suisse] ; A. Zoma [Royaume-Uni] ; K. Kalunian [États-Unis] ; C. Aranow [États-Unis]Source :
- Arthritis care and research [ 0893-7524 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective. We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort. Methods. The Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti-DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated-measures general linear models were used to evaluate SLEDAI-2K and SDI over time between whites and nonwhites. Results. Of the 298 patients, 87% were women, 55% were white, 12% were African American, 14% were Asian, 16% were Hispanic, and 2% were categorized as "other." At enrollment, the mean age was 35.3 years, the mean SLEDAI-2K score was 5.9, and the mean disease duration was 5.5 months. Mean SLEDAI-2K scores decreased in the first year and then remained low. SLEDAI-2K scores were significantly lower at each year in whites compared to nonwhites. Mean SDI scores increased progressively over 5 years; there was no significant difference between whites and nonwhites. As expected, ANA positivity was high and anti-DNA positivity was relatively low at enrollment, and both increased over 5 years. Although lupus anticoagulant increased slightly over 5 years, aCL positivity did not. Conclusion. Disease activity in newly diagnosed patients decreases over their first 5 years, while damage increases. Antibody positivity ran variable courses over this period.
Affiliations:
- Canada, Corée du Sud, Espagne, Islande, Mexique, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Californie, Catalogne, Grand Londres, Grand Manchester, Illinois, Maryland, Midlands de l'Ouest, Pennsylvanie, Région capitale de Séoul, Svealand, État de New York
- Barcelone, Birmingham, Londres, Los Angeles, Manchester, San Diego, Stockholm, Séoul
- Université de Manchester
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Pascal:12-0122182Le document en format XML
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Bernatsky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Montreal General Hospital and McGill University Health Centre</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal General Hospital and McGill University Health Centre</wicri:noRegion></affiliation></author><author><name sortKey="Hanly, J G" sort="Hanly, J G" uniqKey="Hanly J" first="J. G." last="Hanly">J. G. Hanly</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Elizabeth II Health Sciences Centre and Dalhousie University</s1><s2>Halifax, Nova Scotia</s2><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Queen Elizabeth II Health Sciences Centre and Dalhousie University</wicri:noRegion></affiliation></author><author><name sortKey="Isenberg, D" sort="Isenberg, D" uniqKey="Isenberg D" first="D." last="Isenberg">D. Isenberg</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>University College</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A." last="Rahman">A. Rahman</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Instituto Nacional de Ciencias Medicas y Nutricion</s1><s2>Mexico City</s2><s3>MEX</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Instituto Nacional de Ciencias Medicas y Nutricion</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Guerrero, J" sort="Sanchez Guerrero, J" uniqKey="Sanchez Guerrero J" first="J." last="Sanchez-Guerrero">J. Sanchez-Guerrero</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Instituto Nacional de Ciencias Medicas y Nutricion</s1><s2>Mexico City</s2><s3>MEX</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Instituto Nacional de Ciencias Medicas y Nutricion</wicri:noRegion></affiliation></author><author><name sortKey="Wallace, D J" sort="Wallace, D J" uniqKey="Wallace D" first="D. J." last="Wallace">D. J. Wallace</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ginzler, E" sort="Ginzler, E" uniqKey="Ginzler E" first="E." last="Ginzler">E. Ginzler</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>State University of New York Downstate Medical Center</s1><s2>Brooklyn</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>State University of New York Downstate Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Alarcon, G S" sort="Alarcon, G S" uniqKey="Alarcon G" first="G. S." last="Alarcon">G. S. Alarcon</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>University of Alabama</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Merrill, J T" sort="Merrill, J T" uniqKey="Merrill J" first="J. T." last="Merrill">J. T. Merrill</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Oklahoma Medical Research Foundation</s1><s2>Oklahoma City</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Oklahoma Medical Research Foundation</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, I N" sort="Bruce, I N" uniqKey="Bruce I" first="I. N." last="Bruce">I. N. Bruce</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>University of Manchester</s1><s2>Manchester</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G." last="Sturfelt">G. Sturfelt</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>University Hospital Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>University Hospital Lund</wicri:noRegion></affiliation></author><author><name sortKey="Nived, O" sort="Nived, O" uniqKey="Nived O" first="O." last="Nived">O. Nived</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>University Hospital Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>University Hospital Lund</wicri:noRegion></affiliation></author><author><name sortKey="Steinsson, K" sort="Steinsson, K" uniqKey="Steinsson K" first="K." last="Steinsson">K. Steinsson</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Landspitali University Hospital</s1><s2>Reyjkavik</s2><s3>ISL</s3><sZ>20 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Landspitali University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Khamashta, M" sort="Khamashta, M" uniqKey="Khamashta M" first="M." last="Khamashta">M. Khamashta</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>St. Thomas' Hospital and King's College London School of Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Petri, M" sort="Petri, M" uniqKey="Petri M" first="M." last="Petri">M. Petri</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Johns Hopkins University School of Medicine</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Manzi, S" sort="Manzi, S" uniqKey="Manzi S" first="S." last="Manzi">S. Manzi</name><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Allegheny Singer Research Institute, Allegheny General Hospital</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ramsey Goldman, R" sort="Ramsey Goldman, R" uniqKey="Ramsey Goldman R" first="R." last="Ramsey-Goldman">R. Ramsey-Goldman</name><affiliation wicri:level="2"><inist:fA14 i1="18"><s1>Northwestern University and Feinberg School of Medicine</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dooley, M A" sort="Dooley, M A" uniqKey="Dooley M" first="M. A." last="Dooley">M. A. Dooley</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>University of North Carolina</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of North Carolina</wicri:noRegion></affiliation></author><author><name sortKey="Van Vollenhoven, R F" sort="Van Vollenhoven, R F" uniqKey="Van Vollenhoven R" first="R. F." last="Van Vollenhoven">R. F. Van Vollenhoven</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>The Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>26 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Ramos, M" sort="Ramos, M" uniqKey="Ramos M" first="M." last="Ramos">M. Ramos</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Unidad de Enfermedades</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Stoll, T" sort="Stoll, T" uniqKey="Stoll T" first="T." last="Stoll">T. Stoll</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Kantonsspital</s1><s2>Schaffhausen</s2><s3>CHE</s3><sZ>28 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Kantonsspital</wicri:noRegion></affiliation></author><author><name sortKey="Zoma, A" sort="Zoma, A" uniqKey="Zoma A" first="A." last="Zoma">A. Zoma</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Hairmyres Hospital</s1><s2>East Kilbride</s2><s3>GBR</s3><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Hairmyres Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Kalunian, K" sort="Kalunian, K" uniqKey="Kalunian K" first="K." last="Kalunian">K. Kalunian</name><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>University of California School of Medicine</s1><s2>San Diego</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Aranow, C" sort="Aranow, C" uniqKey="Aranow C" first="C." last="Aranow">C. Aranow</name><affiliation wicri:level="2"><inist:fA14 i1="25"><s1>Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0122182</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0122182 INIST</idno><idno type="RBID">Pascal:12-0122182</idno><idno type="wicri:Area/PascalFrancis/Corpus">004838</idno><idno type="wicri:Area/PascalFrancis/Curation">000666</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003652</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003652</idno><idno type="wicri:doubleKey">0893-7524:2012:Urowitz M:evolution:of:disease</idno><idno type="wicri:Area/Main/Merge">009938</idno><idno type="wicri:Area/Main/Curation">009275</idno><idno type="wicri:Area/Main/Exploration">009275</idno><idno type="wicri:Area/Canada/Extraction">000621</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Evolution of Disease Burden Over Five Years in a Multicenter Inception Systemic Lupus Erythematosus Cohort</title><author><name sortKey="Urowitz, M B" sort="Urowitz, M B" uniqKey="Urowitz M" first="M. B." last="Urowitz">M. B. Urowitz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Gladman, D D" sort="Gladman, D D" uniqKey="Gladman D" first="D. D." last="Gladman">D. D. Gladman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ibanez, D" sort="Ibanez, D" uniqKey="Ibanez D" first="D." last="Ibanez">D. Ibanez</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Fortin, P R" sort="Fortin, P R" uniqKey="Fortin P" first="P. R." last="Fortin">P. R. Fortin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Hospital</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto Western Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Bae, S C" sort="Bae, S C" uniqKey="Bae S" first="S. C." last="Bae">S. C. Bae</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Hospital for Rheumatic Diseases and Hanyang University Medical Center</s1><s2>Seoul</s2><s3>KOR</s3><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Gordon, C" sort="Gordon, C" uniqKey="Gordon C" first="C." last="Gordon">C. Gordon</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>University of Birmingham Medical School</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Montreal General Hospital and McGill University Health Centre</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal General Hospital and McGill University Health Centre</wicri:noRegion></affiliation></author><author><name sortKey="Bernatsky, S" sort="Bernatsky, S" uniqKey="Bernatsky S" first="S." last="Bernatsky">S. Bernatsky</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Montreal General Hospital and McGill University Health Centre</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal General Hospital and McGill University Health Centre</wicri:noRegion></affiliation></author><author><name sortKey="Hanly, J G" sort="Hanly, J G" uniqKey="Hanly J" first="J. G." last="Hanly">J. G. Hanly</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Queen Elizabeth II Health Sciences Centre and Dalhousie University</s1><s2>Halifax, Nova Scotia</s2><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Queen Elizabeth II Health Sciences Centre and Dalhousie University</wicri:noRegion></affiliation></author><author><name sortKey="Isenberg, D" sort="Isenberg, D" uniqKey="Isenberg D" first="D." last="Isenberg">D. Isenberg</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>University College</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A." last="Rahman">A. Rahman</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Instituto Nacional de Ciencias Medicas y Nutricion</s1><s2>Mexico City</s2><s3>MEX</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Instituto Nacional de Ciencias Medicas y Nutricion</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Guerrero, J" sort="Sanchez Guerrero, J" uniqKey="Sanchez Guerrero J" first="J." last="Sanchez-Guerrero">J. Sanchez-Guerrero</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Instituto Nacional de Ciencias Medicas y Nutricion</s1><s2>Mexico City</s2><s3>MEX</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Instituto Nacional de Ciencias Medicas y Nutricion</wicri:noRegion></affiliation></author><author><name sortKey="Wallace, D J" sort="Wallace, D J" uniqKey="Wallace D" first="D. J." last="Wallace">D. J. Wallace</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ginzler, E" sort="Ginzler, E" uniqKey="Ginzler E" first="E." last="Ginzler">E. Ginzler</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>State University of New York Downstate Medical Center</s1><s2>Brooklyn</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>State University of New York Downstate Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Alarcon, G S" sort="Alarcon, G S" uniqKey="Alarcon G" first="G. S." last="Alarcon">G. S. Alarcon</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>University of Alabama</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Merrill, J T" sort="Merrill, J T" uniqKey="Merrill J" first="J. T." last="Merrill">J. T. Merrill</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Oklahoma Medical Research Foundation</s1><s2>Oklahoma City</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Oklahoma Medical Research Foundation</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, I N" sort="Bruce, I N" uniqKey="Bruce I" first="I. N." last="Bruce">I. N. Bruce</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>University of Manchester</s1><s2>Manchester</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G." last="Sturfelt">G. Sturfelt</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>University Hospital Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>University Hospital Lund</wicri:noRegion></affiliation></author><author><name sortKey="Nived, O" sort="Nived, O" uniqKey="Nived O" first="O." last="Nived">O. Nived</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>University Hospital Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>University Hospital Lund</wicri:noRegion></affiliation></author><author><name sortKey="Steinsson, K" sort="Steinsson, K" uniqKey="Steinsson K" first="K." last="Steinsson">K. Steinsson</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Landspitali University Hospital</s1><s2>Reyjkavik</s2><s3>ISL</s3><sZ>20 aut.</sZ></inist:fA14><country>Islande</country><wicri:noRegion>Landspitali University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Khamashta, M" sort="Khamashta, M" uniqKey="Khamashta M" first="M." last="Khamashta">M. Khamashta</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>St. Thomas' Hospital and King's College London School of Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Petri, M" sort="Petri, M" uniqKey="Petri M" first="M." last="Petri">M. Petri</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Johns Hopkins University School of Medicine</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Manzi, S" sort="Manzi, S" uniqKey="Manzi S" first="S." last="Manzi">S. Manzi</name><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Allegheny Singer Research Institute, Allegheny General Hospital</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ramsey Goldman, R" sort="Ramsey Goldman, R" uniqKey="Ramsey Goldman R" first="R." last="Ramsey-Goldman">R. Ramsey-Goldman</name><affiliation wicri:level="2"><inist:fA14 i1="18"><s1>Northwestern University and Feinberg School of Medicine</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>24 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dooley, M A" sort="Dooley, M A" uniqKey="Dooley M" first="M. A." last="Dooley">M. A. Dooley</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>University of North Carolina</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>25 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>University of North Carolina</wicri:noRegion></affiliation></author><author><name sortKey="Van Vollenhoven, R F" sort="Van Vollenhoven, R F" uniqKey="Van Vollenhoven R" first="R. F." last="Van Vollenhoven">R. F. Van Vollenhoven</name><affiliation wicri:level="3"><inist:fA14 i1="20"><s1>The Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>26 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Ramos, M" sort="Ramos, M" uniqKey="Ramos M" first="M." last="Ramos">M. Ramos</name><affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Unidad de Enfermedades</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>27 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Stoll, T" sort="Stoll, T" uniqKey="Stoll T" first="T." last="Stoll">T. Stoll</name><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Kantonsspital</s1><s2>Schaffhausen</s2><s3>CHE</s3><sZ>28 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Kantonsspital</wicri:noRegion></affiliation></author><author><name sortKey="Zoma, A" sort="Zoma, A" uniqKey="Zoma A" first="A." last="Zoma">A. Zoma</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Hairmyres Hospital</s1><s2>East Kilbride</s2><s3>GBR</s3><sZ>29 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Hairmyres Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Kalunian, K" sort="Kalunian, K" uniqKey="Kalunian K" first="K." last="Kalunian">K. Kalunian</name><affiliation wicri:level="3"><inist:fA14 i1="24"><s1>University of California School of Medicine</s1><s2>San Diego</s2><s3>USA</s3><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Aranow, C" sort="Aranow, C" uniqKey="Aranow C" first="C." last="Aranow">C. Aranow</name><affiliation wicri:level="2"><inist:fA14 i1="25"><s1>Columbia University Medical Center</s1><s2>New York, New York</s2><s3>USA</s3><sZ>31 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Arthritis care and research</title><title level="j" type="abbreviated">Arthritis care res.</title><idno type="ISSN">0893-7524</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Arthritis care and research</title><title level="j" type="abbreviated">Arthritis care res.</title><idno type="ISSN">0893-7524</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evolution</term><term>Rheumatology</term><term>Systemic lupus erythematosus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lupus érythémateux disséminé</term><term>Evolution</term><term>Rhumatologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort. Methods. The Systemic Lupus International Collaborating Clinics (SLICC) International Research Network, comprising 27 centers from 11 countries, has followed an inception cohort of SLE patients yearly according to a standardized protocol. Of these patients, 298 were followed for a minimum of 5 years and constitute the study population. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K) and damage was assessed using the SLICC/American College of Rheumatology Damage Index (SDI). Antinuclear antibody (ANA), anti-DNA, and anticardiolipin antibody (aCL) levels and lupus anticoagulant were assessed yearly. Descriptive statistics were generated and repeated-measures general linear models were used to evaluate SLEDAI-2K and SDI over time between whites and nonwhites. Results. Of the 298 patients, 87% were women, 55% were white, 12% were African American, 14% were Asian, 16% were Hispanic, and 2% were categorized as "other." At enrollment, the mean age was 35.3 years, the mean SLEDAI-2K score was 5.9, and the mean disease duration was 5.5 months. Mean SLEDAI-2K scores decreased in the first year and then remained low. SLEDAI-2K scores were significantly lower at each year in whites compared to nonwhites. Mean SDI scores increased progressively over 5 years; there was no significant difference between whites and nonwhites. As expected, ANA positivity was high and anti-DNA positivity was relatively low at enrollment, and both increased over 5 years. Although lupus anticoagulant increased slightly over 5 years, aCL positivity did not. Conclusion. Disease activity in newly diagnosed patients decreases over their first 5 years, while damage increases. Antibody positivity ran variable courses over this period.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>Islande</li><li>Mexique</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Catalogne</li><li>Grand Londres</li><li>Grand Manchester</li><li>Illinois</li><li>Maryland</li><li>Midlands de l'Ouest</li><li>Pennsylvanie</li><li>Région capitale de Séoul</li><li>Svealand</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Birmingham</li><li>Londres</li><li>Los Angeles</li><li>Manchester</li><li>San Diego</li><li>Stockholm</li><li>Séoul</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Urowitz, M B" sort="Urowitz, M B" uniqKey="Urowitz M" first="M. B." last="Urowitz">M. B. Urowitz</name></noRegion><name sortKey="Bernatsky, S" sort="Bernatsky, S" uniqKey="Bernatsky S" first="S." last="Bernatsky">S. Bernatsky</name><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A." last="Clarke">A. Clarke</name><name sortKey="Fortin, P R" sort="Fortin, P R" uniqKey="Fortin P" first="P. R." last="Fortin">P. R. Fortin</name><name sortKey="Gladman, D D" sort="Gladman, D D" uniqKey="Gladman D" first="D. D." last="Gladman">D. D. Gladman</name><name sortKey="Hanly, J G" sort="Hanly, J G" uniqKey="Hanly J" first="J. G." last="Hanly">J. G. Hanly</name><name sortKey="Ibanez, D" sort="Ibanez, D" uniqKey="Ibanez D" first="D." last="Ibanez">D. Ibanez</name></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Bae, S C" sort="Bae, S C" uniqKey="Bae S" first="S. C." last="Bae">S. C. Bae</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gordon, C" sort="Gordon, C" uniqKey="Gordon C" first="C." last="Gordon">C. Gordon</name></region><name sortKey="Alarcon, G S" sort="Alarcon, G S" uniqKey="Alarcon G" first="G. S." last="Alarcon">G. S. Alarcon</name><name sortKey="Bruce, I N" sort="Bruce, I N" uniqKey="Bruce I" first="I. N." last="Bruce">I. N. Bruce</name><name sortKey="Isenberg, D" sort="Isenberg, D" uniqKey="Isenberg D" first="D." last="Isenberg">D. Isenberg</name><name sortKey="Khamashta, M" sort="Khamashta, M" uniqKey="Khamashta M" first="M." last="Khamashta">M. Khamashta</name><name sortKey="Zoma, A" sort="Zoma, A" uniqKey="Zoma A" first="A." last="Zoma">A. Zoma</name></country><country name="Mexique"><noRegion><name sortKey="Rahman, A" sort="Rahman, A" uniqKey="Rahman A" first="A." last="Rahman">A. Rahman</name></noRegion><name sortKey="Sanchez Guerrero, J" sort="Sanchez Guerrero, J" uniqKey="Sanchez Guerrero J" first="J." last="Sanchez-Guerrero">J. Sanchez-Guerrero</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Wallace, D J" sort="Wallace, D J" uniqKey="Wallace D" first="D. J." last="Wallace">D. J. Wallace</name></region><name sortKey="Aranow, C" sort="Aranow, C" uniqKey="Aranow C" first="C." last="Aranow">C. Aranow</name><name sortKey="Dooley, M A" sort="Dooley, M A" uniqKey="Dooley M" first="M. A." last="Dooley">M. A. Dooley</name><name sortKey="Ginzler, E" sort="Ginzler, E" uniqKey="Ginzler E" first="E." last="Ginzler">E. Ginzler</name><name sortKey="Kalunian, K" sort="Kalunian, K" uniqKey="Kalunian K" first="K." last="Kalunian">K. Kalunian</name><name sortKey="Manzi, S" sort="Manzi, S" uniqKey="Manzi S" first="S." last="Manzi">S. Manzi</name><name sortKey="Merrill, J T" sort="Merrill, J T" uniqKey="Merrill J" first="J. T." last="Merrill">J. T. Merrill</name><name sortKey="Petri, M" sort="Petri, M" uniqKey="Petri M" first="M." last="Petri">M. Petri</name><name sortKey="Ramsey Goldman, R" sort="Ramsey Goldman, R" uniqKey="Ramsey Goldman R" first="R." last="Ramsey-Goldman">R. Ramsey-Goldman</name></country><country name="Suède"><noRegion><name sortKey="Sturfelt, G" sort="Sturfelt, G" uniqKey="Sturfelt G" first="G." last="Sturfelt">G. Sturfelt</name></noRegion><name sortKey="Nived, O" sort="Nived, O" uniqKey="Nived O" first="O." last="Nived">O. Nived</name><name sortKey="Van Vollenhoven, R F" sort="Van Vollenhoven, R F" uniqKey="Van Vollenhoven R" first="R. F." last="Van Vollenhoven">R. F. Van Vollenhoven</name></country><country name="Islande"><noRegion><name sortKey="Steinsson, K" sort="Steinsson, K" uniqKey="Steinsson K" first="K." last="Steinsson">K. Steinsson</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Ramos, M" sort="Ramos, M" uniqKey="Ramos M" first="M." last="Ramos">M. Ramos</name></region></country><country name="Suisse"><noRegion><name sortKey="Stoll, T" sort="Stoll, T" uniqKey="Stoll T" first="T." last="Stoll">T. Stoll</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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